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优化内表瘤的结果:当代审查

Zhenjiang Pan^1,2, Jing Bao^1,2, Shepeng Wei^1,2

¹Department of Neurosurgery, Shidong Hospital, Yangpu District, Shanghai, China.

Frontiers in oncology

|June 25, 2025

概括

内膜瘤,儿童的质瘤,需要多式治疗. 在分子分析和分类方面的进步改善了对这些罕见的中枢神经系统瘤的诊断和预后.

科学领域:

神经瘤学神经瘤学
儿科瘤学儿科瘤学
分子病理学分子病理学

背景情况:

内膜瘤是源自心室系统内膜内的质瘤.
脊髓瘤是儿童中第二常见的原发性脊髓瘤,占儿童中枢神经系统瘤的不到10%.
临床表现因瘤的位置而异,通常涉及水脑或焦点神经学缺陷.

研究的目的:

审查当前关于内膜瘤的发病,分类,诊断和治疗的知识.
突出分子分析在理解和管理这些瘤中的不断变化的作用.
强调多学科护理对优化患者治疗结果的重要性.

主要方法:

综合关于内膜瘤的当前文献.
基于2021年世卫组织CNS5分类的组织学,解剖学和分子特征的整合.
对包括MRI和脑脊液分析在内的诊断方式的审查.

主要成果:

2021年世卫组织CNS5分类确定了具有预后意义的子组,例如后A组 (PFA) 和 supratentorial ZFTA-fusion ependymomas.
最大安全的手术切除是主要的治疗方法,在患有高度瘤的1岁以上儿童中,通常随后是辅助放射治疗.
十年整体生存率在50%至75%之间,受切除程度,分子亚型和患者年龄的影响.

结论:

内膜瘤需要一个综合的方法,结合手术,放射治疗和化疗,与分子亚型指导治疗策略.
尽管取得了进展,但预后仍然受到警,这强调了需要继续研究和专业护理的需要.
分子分析对准确的诊断,预后和针对儿科膜瘤的向治疗开发越来越重要.

关键词:

总体整体切除总体切除内表瘤是一种内表瘤.分子分类的分子分类.儿科神经瘤学儿童神经瘤学辐射疗法辐射疗法

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