与成人皮下大脑体积相关的常见遗传变异也与出生时的皮下大脑体积有关
Harriet Cullen1,2, Konstantina Dimitrakopoulou3, Hamel Patel4
1School of Biomedical Engineering and Imaging Sciences, Centre for the Developing Brain, King's College London, London, United Kingdom.
影响成人的大脑结构的常见遗传变异在胎儿发育期间也很活跃. 这项研究证实,影响成年皮质下大脑体积的遗传因素在出生时就存在,影响婴儿大脑发育.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发育生物学 发展生物学
背景情况:
- 全基因组关联研究 (GWAS) 已经确定了与成人皮层下大脑体积相关的单核酸多态 (SNP).
- 以前的研究主要集中在成年人群中,遗传变异性在早期大脑发育中的作用未被充分探索.
研究的目的:
- 调查常见遗传变异对胎儿和围产期大脑发育的影响.
- 为了确定与成人皮层下大脑体积相关的遗传因素是否也与出生有关.
主要方法:
- 检查了以前与成年皮质下大脑体积相关的八种特定SNP,在一组208名满期出生的婴儿中.
- 计算了关键的皮下结构 (杏仁体,脑干,尾状体,海马体,皮体,皮体,丘脑体) 的全基因组多基因分数.
- 评估了这些SNP和多基因分数与相应的新生儿大脑体积之间的关联.
主要成果:
- SNP rs945270显示出与出生时膜体积的显著关联,反映了成年人的发现.
- 新生儿海马体,脑干,皮质体和丘脑体的新生儿体积与他们各自的全基因组多基因分数显著相关,这些分数来自成人数据.
结论:
- 常见的遗传变异在胎儿发育和成年期间在塑造皮质下大脑体积方面起着至关重要的作用.
- 这些发现强调了遗传因素对大脑结构的早期影响,从产前阶段延伸到成年生活.
更多相关视频
09:06Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
08:22A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
Published on: December 1, 2017
相关概念视频
Biological Influences on Intelligence
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Variation
Genes exist in different versions called alleles,...
Genetic Lingo
