有氧运动通过海马体IL-33/NF-κB信号调制来改善动脉样硬化引起的认知障碍
Jianwei Peng1, Zaoshang Chang2, Jinyun Wang1
1Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, China.
Frontiers in physiology
|June 25, 2025
概括
有氧运动通过减少大脑炎症,改善了动脉样硬化 (AS) 的小鼠的认知功能. 这种干预降低了关键的炎症标志物,提高了认知表现,提供了潜在的治疗策略.
科学领域:
- 心血管科学 心血管科学
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
背景情况:
- 动脉样硬化 (AS) 是一种普遍的心血管疾病,经常与认知功能障碍有关.
- 关联AS诱导的认知障碍和潜在的治疗干预的潜在机制需要进一步研究.
研究的目的:
- 为了研究有氧运动对饮食诱导动脉样硬化症的apolipoprotein E淘汰赛 (ApoE-/-) 小鼠的认知障碍的影响.
- 探索分子机制,包括神经炎症和特定的信号通路,在这个模型中通过炼调节.
主要方法:
- 在使用高脂肪,高胆固醇饮食 (HFHCD) 的雄性ApoE小鼠中诱导了动脉样硬化.
- 评估了认知表现和大动脉斑块负担.
- 在AS小鼠的静止和运动组中实施了为期10周的有氧运动干预,随后对海马炎症标志物,微质激活和信号通路 (IL-33,NF-κB) 进行了分析.
主要成果:
- 与野生类型对照相比,AS小鼠表现出显著的大动脉斑块形成和认知缺陷.
- 在AS小鼠中,有氧运动干预减少了大动脉斑块,改善了认知功能,并增强了大脑血流.
- 运动降低了海马IL-33表达,抑制了NF-κB激活,减少了M1微质极化,降低了促炎细胞因子 (IL-6,TNF-α,IL-1β).
结论:
- 有氧运动有效地改善了动脉样硬化的小鼠模型中的认知障碍.
- 这些益处是由通过降低IL-33表达和NF-κB通路抑制来减少神经炎症的介导.
- 运动干预代表了一种有前途的非药物战略,用于管理与动脉样硬化相关的认知衰退.
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