治疗时间启动及其对所有原因死亡率的影响:来自监测,流行病学和最终结果数据库的见解
Song Peng Ang1,2, Eunseuk Lee1, Jia Ee Chia2
1Department of Medicine, Rutgers Health/Community Medical Center, Toms River, NJ, USA.
World journal of oncology
|June 25, 2025
概括
延迟癌症治疗开始 (TTI) 会增加主要癌症的死亡风险. 解决TTI的社会人口差异对于改善公平的癌症护理和生存结果至关重要.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 推迟启动癌症治疗显著影响患者的生存结果.
- 延迟治疗的影响因癌症类型,阶段和患者人口统计学而异.
- 本研究研究了治疗开始时间 (TTI) 与常见癌症全因死亡率之间的关联.
研究的目的:
- 检查多种常见癌症中TTI和全因死亡率之间的关联.
- 根据癌症类型和患者社会人口统计数据,评估TTI对死亡率的影响差异.
- 确定TTI的差异及其与生存结果的相关性.
主要方法:
- 来自SEER数据库 (2015-2020) 的991,771名成年癌症患者的回顾性队列分析.
- TTI分为0-1,2-5,6-9和≥10个月的类别.
- 经对共变量调整的考克斯比例危险模型评估了TTI对所有原因死亡率的影响.
主要成果:
- 较长的TTI与所有原因死亡率的增加显著相关 (HR1.02-1.23,P < 0.001).
- 年龄较大,男性性别,未婚状态和非西班牙裔黑人种族与较高的死亡率有关.
- 与乳腺癌,前列腺癌和结直肠癌相比,肺癌患者的死亡率更高.
结论:
- 增加的TTI独立地与主要癌症所有原因死亡率显著上升有关.
- 在TTI和结果的社会人口学差异突出系统性障碍.
- 需要有针对性的干预措施来改善公平的癌症护理和生存结果.
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