在COVID-19封锁期间的情绪压力:负面的X/Twitter帖子如何与大脑恐惧网络变化相关
Eric Guedj1, Jacques-Yves Campion2,3, Tatiana Horowitz1
1Aix Marseille Univ, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Nuclear Medicine Department, Marseille, France.
Frontiers in nuclear medicine
|June 25, 2025
概括
随着COVID-19的封锁,恐惧回路中的大脑代谢受到负面影响,特别是右腹中腹前额皮质和前带皮质. 这突出了大脑的功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- COVID-19 流行病和相关的封锁对全球心理健康产生了重大影响.
- 在封锁期间,恐惧和不确定性等负面情绪加剧了.
- 易受伤害的人群经历了加剧的心理痛苦.
研究的目的:
- 为了调查与法国首次COVID-19封锁的心理背景相关的大脑代谢变化.
- 关联锁定期间的公众情绪与患者的神经活动.
主要方法:
- 利用来自X/Twitter数据的复合负面情绪评分作为心理背景的代理.
- 与95名神经病患者的全脑基于voxel的[18F]FDG PET成像相关的每日负面情绪得分.
- 使用统计参数映射 (SPM) 进行相关性分析 (p < 0.001,k > 108).
主要成果:
- 在右腹中介前额叶皮质 (vmPFC) 和前带皮质 (ACC) 中发现了负面情绪得分和新陈代谢之间的显著负相关性.
- 确定这些区域是大脑恐惧电路的关键组成部分.
- 区域间的相关性分析揭示了右边边缘主导网络,包括杏仁体,海马体,质体和基底.
结论:
- 正确的vmPFC/ACC对社会情绪压力因素敏感,可能是疫情期间心理障碍增加的潜在原因.
- 这些发现表明,大脑基质是与流行病相关的心理健康问题.
- 需要进一步的研究来验证这些结果,并探索集体压力对大脑的纵向影响.
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