低频和马振荡之间的交叉频率合改变了抑郁症认知生物型的认知生物型
Hongli Wang1,2, Xiaoning Shi1,2, Chenyang Wang1,2
1Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Frontiers in psychiatry
|June 25, 2025
概括
这项研究揭示了抑郁症认知亚型中大脑波合的改变,确定了精确治疗的潜在生物标志物. 具体来说,在闭眼状态下观察到,theta,alpha和beta波段与马振荡的合减少.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 计算生物学 计算生物学
背景情况:
- 抑郁症的认知生物型是一种独特的亚型,具有独特的神经相关性和临床特征.
- 异常的神经振荡,特别是马振荡,与抑郁症的认知功能障碍有关.
- 在这种子类型中,低频和马振荡之间的交叉频率合 (CFC) 仍未得到充分探索.
研究的目的:
- 在患有抑郁症认知生物型的患者中研究低频和马振荡之间的交叉频率合 (CFC) 模式.
- 探索抑郁症患者中CFC和认知功能之间的关系.
主要方法:
- 141名患有抑郁症缓解的患者使用 MATRICS 共识认知电池 (MCCB) 进行了评估.
- 患者被分为认知生物型 (n=56) 和非认知障碍 (n=85) 分组.
- 电脑电图 (EEG) 数据被分析为CFC,特别是阶段幅度合 (PAC),在三角形,三角形,α,β振荡与马振荡之间的眼睛开放和闭眼状态.
主要成果:
- 在认知生物型组中观察到PAC值的下降,特别是在眼睛关闭状态期间的叶内,在,α和β振荡与马振荡之间.
- 在闭眼状态期间,在认知生物型中发现了增加的三角-马合.
- 在眼睛打开状态下,没有发现CFC的显著差异.
- 在闭眼状态下,认知功能和CFC之间发现了显著的相关性.
结论:
- 叶的交叉频率合变化是抑郁症认知生物型的特征.
- 这些发现增强了对抑郁症认知缺陷背后的神经生理机制的理解.
- 已识别的CFC模式可以作为抑郁症治疗中精准医学方法的潜在生物标志物.
相关概念视频
Depressive Disorders: Etiology
173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Depressive Disorders: MDD and Dysthymia
225
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
225
G-protein Coupled Receptors
121.8K
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
121.8K
Depression: Overview
369
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
369
Negative and Cognitive Symptoms of Schizophrenia
129
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
129


