下心率变化与风湿性关节炎的高疾病活动,功能障碍和炎症有关:一个横截面研究
Suchitra Lakshmi Goda1, Madhumitha Haridoss1,2, Krishnamurthy Venkataraman3
1Health Technology Assessment Resource Centre, ICMR-National Institute of Epidemiology, Chennai, India.
Mediterranean journal of rheumatology
|June 25, 2025
概括
风湿性关节炎 (RA) 中心率变化 (HRV) 降低与疾病活动增加和功能障碍相关. 这突出了HRV作为心血管自主功能的潜在标记在RA管理.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 自主神经系统的自主神经系统
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,影响心血管健康.
- 心脏自主神经病变是RA患者常见的并发症.
- 心率变化 (HRV) 是自主调节的非侵入性指标,在RA中经常被发现是减少的.
研究的目的:
- 调查HRV与类风湿性关节炎疾病活性之间的关联.
- 探索HRV和RA特定参数 (如功能状态和生活质量) 之间的关系.
主要方法:
- 这项研究包括来自印度南部一家三级医院的320名成年RA患者.
- 收集的数据包括社会人口统计学,临床,实验室和HRV参数.
- 疾病活动,功能状态和生活质量分别使用DAS-28,HAQ和EuroQol-5D进行评估. 使用了斯皮尔曼的相关性和线性回归分析.
主要成果:
- 在HRV参数和RA疾病活动标志物 (DAS-28,HAQ,ESR) 之间发现了显著的负相关性.
- 线性回归显示,较低的标准偏差率每分钟跳动 (SDNN) 与更高的HAQ分数相关,表明功能能力较差.
结论:
- 降低RA患者的HRV与增加的疾病活性,功能障碍和炎症有关.
- HRV可以作为评估RA中心血管自主功能的宝贵工具,有助于患者管理和预后.
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