感染哺乳动物细胞的病原体通过硫化糖氨酸甘油感染哺乳动物细胞
Jessica S Morris1, Paul A Dawson1
1Mater Research Institute - University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.
Frontiers in cellular and infection microbiology
|June 25, 2025
概括
葡萄糖氨基甘油对病原体感染至关重要. 这项研究审查了95种病原体,包括病毒和细菌,这些病原体利用这些分子入侵人类细胞,为未来的治疗提供了资源.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 硫化糖氨基甘油 (GAG),如肝和皮肤硫酸盐,对于哺乳动物生理学至关重要,在细胞表面和细胞外基质中发现.
- 病原体与特定的GAG结合是已知的感染机制,有300多项研究记录了这种相互作用.
- 缺乏对所有利用GAG感染的病原体进行全面的分类.
研究的目的:
- 提供所有已知的病原体的概述,这些病原体利用糖氨基 (GAG) 来增强人类细胞的结合和/或感染.
- 创建一个精心策划的病原体列表,这些病原体在感染期间与GAG相互作用.
- 为了突出GAG在病原体感染中的保存和广泛使用.
主要方法:
- 使用PubMed进行了系统的文献搜索.
- 搜索术语包括"硫酸盐/硫酸盐"",病原体"",病毒"",细菌"",寄生虫"",感染"和"糖氨基氨基甘油".
- 经过同行评审的原始研究文章被精选,以使用GAG识别病原体.
主要成果:
- 葡萄糖氨基甘 (GAG) 在59种病毒的感染过程中被利用.
- 28种细菌物种和8种其他病原体 (寄生原生虫,) 也使用GAG感染.
- 这代表了大量的病原体利用GAG进行宿主细胞相互作用.
结论:
- 葡萄糖氨基甘 (GAG) 被广泛而一致地用于各种各样的病原体,以促进感染.
- 这些发现强调了GAG介导的病原体进入机制的保存性.
- 这份精心策划的清单是开发针对GAG相互作用病原体的有针对性的治疗策略的宝贵资源.
相关概念视频
Proteoglycans
4.0K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.0K
Glycosaminoglycans
5.2K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
5.2K
Skin Diseases and Disorders
4.3K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.3K
Fungal Phylum Microsporidia
128
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
128
Diversity of Protists II
151
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
151
Infection
8.8K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.8K


