一种抗菌水凝涂层,含有pH调节的里芬辛,用于预防导管相关的感染
Jia-Yin You1, Jia-Rong Wang1, Zhao-Yang Chen2
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China. renkf@zju.edu.cn.
Journal of materials chemistry. B
|June 25, 2025
概括
这项研究开发了一种可调节的多电解质水凝涂层,用于医疗导管. 涂层提供抗菌,滑和抗凝固特性,以减少感染并改善导管的性能.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 医疗设备工程 医疗设备工程
背景情况:
- 医疗导管易受细菌感染,导致设备故障和患者并发症.
- 抗菌涂层是缓解导管相关感染的关键策略.
- 开发具有滑性和抗凝固特性等额外好处的多功能涂层是非常理想的.
研究的目的:
- 为医疗导管创建一个具有可调节抗生素载荷的多电解质水凝涂层.
- 为了给水凝涂层赋予抗菌,滑和抗凝特性.
- 评估涂层在减少导管相关问题的性能.
主要方法:
- 使用启动器预陷和in situ紫外线启动,制备一个交联的多2-烯-2-甲基硫酸盐 (pAN) 水凝涂层.
- 通过静电相互作用将疏水性里法素 (RIF) 装入pAN水凝中,通过pH调节实现可调节的装载.
- 描述水凝涂层的抗菌功效,滑性 (摩擦系数) 和抗凝性质.
主要成果:
- 在pAN水凝涂层中,Rifampicin (RIF) 的有效和可调节的负载达到pH2.0时达到119.3±10.8μg cm−2,在广泛的pH范围 (2.0-9.5) 中保持高负载.
- 硫酸聚电解质涂层表现出优异的水友性滑性,摩擦系数低于0.03.
- 涂层还显示出显著的抗凝固特性.
- 开发的水凝涂层具有多功能,具有抗菌,滑和抗凝特性.
结论:
- 一种新的聚电解质水凝涂层 (pAN) 已成功开发用于医疗导管.
- 该涂层通过RIF加载提供可调节的抗菌活性,并具有有益的滑和抗凝性质.
- 这种多功能涂层为提高医疗聚合物基导管的性能和减少相关感染提供了一个有希望的策略.
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