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Updated: Sep 18, 2025

Mouse In Vivo Placental Targeted CRISPR Manipulation

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[胎盘组织转录组作为识别大产科综合征分子机制的工具]

E A Trifonova^1,2,3, A V Markov¹, A A Zarubin¹

¹Research Institute of Medical Genetics, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, 634050 Russia.

Molekuliarnaia biologiia

|June 25, 2025

概括

研究人员在妊娠并发症中发现了64个失调的基因,如先兆子和子宫内生长限制 (IUGR). 确定了关键的基因和途径,为产科综合征的风险评估和向治疗提供了潜在的生物标志物.

科学领域:

基因组学和分子生物学
产科和妇科产科和妇科
病理生理学病理生理学

关键词:

不同表达的基因.胎儿生长限制限制胎儿生长伟大的产科综合征.胎盘胎盘胎盘胎盘孕前症是什么意思转录组 (transcriptome) 是一个转录组.

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...