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Updated: Jun 18, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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[优化磁性纳米粒子基于多克索鲁比输送系统的细胞毒性]

A I Kurtova1, A V Svetlakova1, O A Kolesnikova1

  • 1Institute of Future Biophysics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow oblast, 141700 Russia.

Molekuliarnaia biologiia
|June 25, 2025
PubMed
概括

在沉积条件下将纳米颗粒加载到多克索鲁比 (DOX) 中,可显著提高药物含量和释放量. 这种优化的纳米粒子输送系统显示了对乳腺癌细胞的细胞毒性增加,提供了一个有前途的癌症治疗方法.

关键词:
德克索鲁比辛 (doxorubicin) 是一种药物.纳米颗粒是一种纳米粒子.瘤治疗是一种瘤疗法.有针对性的交付目标.

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Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.