关于从神经内分泌瘤中产生的腹转移的管理的共识指南
David G Su1, Leanne M Brown1, Varun V Bansal1
1Yale School of Medicine, New Haven, Connecticut, USA.
Cancer
|June 25, 2025
概括
这一共识为管理带有腹膜转移 (PM) 的神经内分泌瘤 (NENs) 提供了临床指导. 建议采用多学科方法和特定级别的治疗方法,包括对低级别的NEN进行手术和对高级别的NEN进行全身治疗.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 带有腹膜转移 (PM) 的神经内分泌瘤 (NEN) 存在独特的管理挑战,原因是它们的罕见性和各种表现.
- 现有的临床指南需要更新,以反映当前的理解和共识.
研究的目的:
- 更新2018年芝加哥共识指南,以管理与PM的NEN.
- 建立基于专家意见和现有证据的共识驱动的临床途径.
主要方法:
- 一种经过修改的Delphi技术,由107名参与者进行两轮投票.
- 快速的文献审查,以评估支持证据.
- 评估不同临床管理区块的协议水平.
主要成果:
- 在关键管理原则上达成强有力的共识 (>90%).
- 强烈推多学科护理,包括心理社会支持.
- 根据NEN等级分层的治疗策略:对于差异很好的1-2级NENs的细胞减少手术,以及对3级NENs的全身治疗,在某些情况下进行手术.
结论:
- 这种共识为患有PM的NEN提供了重要的临床途径,解决了现有证据的低水平.
- 强调需要高质量的研究,以进一步完善管理策略.
- 强调个性化,多学科的方法,根据疾病程度和患者的症状量身定制.
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