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Updated: Sep 18, 2025

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在儿童中使用抗生素的生理学基础的药物动力学建模:对基于模型的精确剂量计的观点

Ryota Tanaka1,2, Kei Irie1, Tomoyuki Mizuno1,3

  • 1Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Antibiotics (Basel, Switzerland)
|June 25, 2025
PubMed
概括

基于生理学上的药理动力学 (PBPK) 建模通过预测药物行为来优化儿童的抗生素剂量. 这种方法增强了基于模型的精确剂量 (MIPD) 以改善治疗结果和减少儿科患者的毒性.

关键词:
抗生素 抗生素是一种抗生素.基于模型的精确剂量定量.儿科 儿科 儿科 儿科基于生理学的药物动力学建模.

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