在可见光和近红外光激发下对甲状腺和甲状腺的自发光成像
Zhenguo Wu1, Sam M Wiseman2, Haishan Zeng1
1BC Cancer Research Institute, University of British Columbia, Vancouver, BC V5Z 1L3, Canada.
Biosensors
|June 25, 2025
概括
近红外 (NIR) 自流光成像最好区分甲状腺腺瘤与甲状腺组织在手术期间. 这种方法为识别异常的副甲状腺提供了最佳的对比度,改善了手术结果和患者安全.
科学领域:
- 光学成像技术的成像
- 手术技术 手术技术
- 生物医学光学 生物医学光学
背景情况:
- 在手术期间对甲状腺的鉴定是困难的,因为它的小尺寸和外观与周围组织相似.
- 附甲状腺意外损伤可能导致严重的并发症,如低血症.
- 副甲状腺和甲状腺组织的自身光特性对于开发非侵入性检测方法至关重要.
研究的目的:
- 为了比较各种激发波长 (可见于NIR) 的副甲状腺腺瘤和甲状腺组织的高分辨率自光成像.
- 评估不同激发波长的有效性,以区分甲状腺腺瘤和甲状腺组织.
主要方法:
- 开发了一种桌面自光成像系统,用于ex vivo样本分析.
- 在可见 (405,454,520,628 nm) 和近红外 (NIR,780 nm) 激发波长下获得的图像.
- 描述并比较了每个激发波长的副甲状腺腺瘤的自光成像特征.
主要成果:
- 可见光激发产生了比NIR光更强的副甲状腺腺瘤自光.
- 尼尔射线 (780nm) 刺激提供了副甲状腺腺瘤和甲状腺组织之间的最佳强度差异/对比.
- 在NIR激发下,高光点在可见激发下也表现出高光;异质模式很常见.
结论:
- 在手术期间,NIR激发是将副甲状腺腺瘤与甲状腺组织区分开来最佳的.
- 自体光成像,特别是NIR激发,可以帮助在非侵入性检测甲状腺腺瘤.
- 进一步开发自光成像系统可以提高手术精度和患者安全.
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