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Updated: Sep 18, 2025

High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes
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5' DREDGE:通过目标基因的5' UTR直接重复启用基因表达的下调调节

Sagar J Parikh1, Heather M Terron1, Luke A Burgard1,2

  • 1Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.

Cells
|June 25, 2025
PubMed
概括

这项研究引入了DREDGE (直接重复启用基因表达的降低调节),这是一种基于CRISPR的新型系统,用于精确的基因控制. 通过准RNA序列,DREDGE提供高度选择性和完全可逆的基因沉默,扩大其用于基因表达调节的实用性.

关键词:
克里斯普尔是什么意思?克里斯普尔是什么意思?一个漂浮的海.直接重复的重复输激素核酸酶的作用是什么基因调节 基因调节 基因调节

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