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来自Poria cocos的溶性β-葡萄糖的结构和凝特性

Zhixing Li¹, Chenglei Sun², Fan Wang¹

¹College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Gels (Basel, Switzerland)

|June 25, 2025

概括

来自Poria cocos (APCP) 的溶性多糖化物被转化为稳定的水凝. 这种新型的APCPP水凝平台促进了绿色银纳米粒子的合成,并显示出显著的抗菌活性.

科学领域:

生物材料科学生物材料科学
聚合物化学聚合物化学
纳米技术纳米技术

背景情况:

来自Poria cocos (APCP) 的溶性多糖因溶解性和生物可用性差而未得到充分利用.
APCP的β-(1→3) - 葡萄糖骨干表明了功能应用的潜力.

研究的目的:

为了研究APCP的结构性质.
为了探索APCPP的凝行为.
评估APCPP在减少银离子和纳米粒子形成方面的能力.

主要方法:

APCP的结构特征 (分子量,PDI).
通过pH介导的水凝形成 (APCPH).
在现场合成银纳米粒子 (AgNPs) 在APCPH矩阵内.
评估水凝膨胀,机械强度,热稳定性和抗菌活性.

主要成果:

APCP是一种同质的β-(1→3) -D-葡萄糖 (314.2 kDa,PDI 1.32).
稳定的APCPP水凝 (APCPH) 形成了可调节性质,高膨胀率 (>590%) 和热稳定性.
APCPH作为绿色AgNP合成的矩阵,形成Ag-APCP水凝.
Ag-APCP水凝对 Staphylococcus pseudintermedius (5.31毫米抑制区) 显示出显著的抗菌活性.

结论:

使用不足的APCPP可以转换为多功能水凝平台.
这个平台使银纳米粒子的绿色合成成为可能.
由此产生的Ag-APCP水凝对生物医学应用具有前景,特别是在抗菌疗法中.

关键词:

波里亚可可斯 (Poria cocos) 是一种可口可口的植物.这是一种性溶解的多糖.这是一种水凝.贝塔-葡萄糖是什么?

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