在海鲜中金属和矿物质的综合风险评估,使用生物可访问性纠正
Ștefania-Adelina Milea1, Ira-Adeline Simionov1,2, Nina-Nicoleta Lazăr1
1REXDAN Research Infrastructure, "Dunărea de Jos" University of Galati, 98 George Coșbuc Street, 800385 Galati, Romania.
Journal of xenobiotics
|June 25, 2025
概括
评估了各种物种的海鲜生物可访问性和健康风险. 虽然的生物可访问性显著增加,但重金属的整体风险很低,这表明安全消费.
科学领域:
- 食品科学和毒理学 食品科学和毒理学
- 海洋生物学和公共卫生
- 营养化学 营养化学
背景情况:
- 海鲜是营养的重要来源,但可能含有有毒元素,需要进行风险评估.
- 了解金属和矿物质的生物可访问性对于准确的健康风险评估至关重要.
- 热加工可以改变海鲜中元素的含量和生物可用性.
研究的目的:
- 在热处理之前和之后,量化各种海鲜物种中的矿物质和重金属.
- 通过模拟消化来确定这些元素的生物可访问性.
- 通过确定的毒理学参数来评估潜在的消费者健康风险.
主要方法:
- 在双动物,类动物,头足动物和甲类动物中分析矿物质 (P,S,K,Ca,Se) 和重金属 (Cd,Pb,Ni,Cr,Fe,Zn,Co,Mn,As) 含量.
- 在体外模拟胃肠道消化,以测量元素的生物可访问性.
- 估计每日摄入量 (EDI),危险指数 (HI) 和癌症风险 (CR) 的计算用于风险评估.
主要成果:
- (Pb) 的生物可访问性在加工后显著增加,在某些物种中达到100%.
- 大多数金属质的生物可访问性仍然低于100%,表明部分吸收.
- (K) 和硫 (S) 的矿物质生物可访问性最高 (高达23%).
- 观察到Mytilus gigas (Cr,Cu,Zn) 的金属摄入率最高.
- 对所有分析物种的危险指数和癌症风险值都低于安全值.
结论:
- 根据危害指数和癌症风险评估,海鲜消费对健康没有重大风险.
- 热处理对金属的生物可访问性产生影响,而的含量显著增加.
- 该研究为平衡海鲜的营养益处与潜在的毒理问题提供了一个框架.
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