金属,PCB,二氧化物和对心血管功能障碍的联合作用
Bolanle Akinyemi1,2, Emmanuel Obeng-Gyasi1,2
1Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
Journal of xenobiotics
|June 25, 2025
概括
环境污染物如重金属和PCB会影响心血管健康. 联合暴露显示了对血压和脂质的复杂影响,突出了污染物混合物的风险.
科学领域:
- 环境健康 环境健康
- 心血管毒理学心血管毒理学
- 公共卫生 公共卫生
背景情况:
- 对重金属,PCB,二氧化物和 furan 的环境暴露与心血管问题有关.
- 这些多种污染物的综合作用尚不清楚.
研究的目的:
- 调查重金属,PCB,二氧化物和对心血管风险指标的联合影响.
- 分析使用NHANES数据在美国成年人代表性样本中的关联.
主要方法:
- 使用的生物标志物为,,,PCB,二氧化和 furan.
- 评估心血管结果,包括血压,弗雷明汉风险评分 (FRS) 和脂质概况.
- 用多变量线性回归和贝叶斯内核机器回归 (BKMR) 进行分析,调整为共变量.
主要成果:
- 暴露于与血压升高和HDL胆固醇变化有关.
- 暴露于PCB与缩血压和FRS的增加有关,其中PCB156和PCB126是主要的贡献者.
- 富兰与失脂症 (增加的LDL,总胆固醇,甘油三) 有着强烈的关联.
- 综合污染物负担与较高的血压和风险得分相关,但脂质水平较低.
结论:
- 污染物混合物对心血管健康表现出结果特异性的影响.
- 对多种环境污染物的慢性低水平暴露可能会导致心血管功能障碍.
- 需要进一步的纵向研究来证实这些发现,并为降低风险的策略提供信息.
相关概念视频
The Periodic Table and Organismal Elements
20.3K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
20.3K
Types of Toxins
2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K
Toxic Reactions: Overview
1.2K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.2K
Coronary Artery Disease I: Introduction
69
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
69
Psychoneuroimmunology: Cardiovascular Disease
82
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
82
Coronary Artery Disease II: Pathophysiology
42
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
42


