从使用交联聚乙醇涂层的织品中控制释放水友活性剂
Limor Mizrahi1, Rotem Kelman1, Efrat Shtriker1
1Department of Polymer Materials Engineering, Shenkar College, Ramat-Gan 5252626, Israel.
Journal of functional biomaterials
|June 25, 2025
概括
这项研究开发了使用交联聚乙醇 (PVA) 涂层进行控制释放艾伦因的功能性织物. PVA:CA涂层提供更快的释放,而PVA:PAA涂层为生物医学应用提供持续的释放.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 具有活性物质释放的功能性织物对于生物医学和化品用途至关重要.
- 需要控制释放系统来提高治疗疗效和患者的遵守性.
研究的目的:
- 制造用交联聚乙醇 (PVA) 涂覆的无布,用于封装和控制艾伦的释放.
- 为了比较与酸 (CA) 与聚烯酸 (PAA) 交联的PVA涂层的性能.
主要方法:
- 使用CA或PAA涂上交联PVA的无布的制造.
- 使用凝含量,DSC和DMA进行涂料的表征.
- 评估胀行为和阿兰托因释放动力学.
主要成果:
- 与PVA:PAA涂层相比,PVA:CA涂层的交叉连接密度更高.
- 在30分钟内,PVA:PAA 7:3膜呈现出62%的胀;在60分钟内,PVA:CA 7:3膜呈现出36%的胀.
- 在8小时内,PVA:CA 7:3释放了97%的阿兰托因;在20小时内,PVA:PAA 7:3释放了96%的阿兰托因.
结论:
- 交叉连接化学显著影响PVA涂层面料中的艾伦因释放特征.
- PVA:CA涂层提供快速释放,适合立即效果应用.
- PVA:PAA涂层能够持续释放,非常适合长时间的治疗作用.
更多相关视频
10:09Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
Published on: June 30, 2018
8.4K
08:59A Freeze-Thawing Method to Prepare Chitosan-Polyvinyl alcohol Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
17.9K
相关概念视频
Types of Step-Growth Polymers: Polyesters
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Curing Methods
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Waterproofing and Anti-Bacterial Admixtures in Concrete
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
Bioreactor Controls-I
Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
