在巴西,在患有和没有COVID-19的血液病患者的侵入性阿斯伯吉洛症中使用伊萨夫康纳的现实世界经验
Larissa Simão Gandolpho1,2, Vinicius Ponzio1,2, Marjorie Vieira Batista3
1Division of Infectious Diseases, Escola Paulista de Medicina-Universidade Federal de São Paulo, São Paulo 04023-900, SP, Brazil.
Journal of fungi (Basel, Switzerland)
|June 25, 2025
概括
伊萨夫可纳显示出良好的耐受性和疗效治疗入侵性阿斯伯吉洛症在巴西患者血液恶性瘤. 这项现实研究支持其使用,特别是在高风险人群中.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 侵入性阿斯伯吉洛症对患有血液性恶性瘤的患者构成重大威胁.
- 对于中等收入国家的伊萨夫可纳,现实世界数据有限.
- 伊萨夫可纳是一种广泛的三醇抗真菌剂.
研究的目的:
- 为了评估 isavuconazole 的临床反应率和耐受性.
- 为了评估 isavuconazole 在巴西高风险人群中的有效性.
- 为了研究患有血液性恶性瘤和侵入性阿斯伯吉洛症的患者的结局.
主要方法:
- 多中心,回顾性研究设计.
- 包括可能或已被证明具有侵入性阿斯伯吉洛症的患者.
- 来自巴西四个医疗中心的数据收集.
主要成果:
- 分析了50名患有侵入性阿斯伯吉洛症的患者.
- 在6周观察到60%的总生存率.
- 没有报告因毒性而停止治疗.
- 之前的COVID-19感染与较低的生存率相关 (44%与69%).
结论:
- 现实世界的证据支持isavuconazole的疗效和耐受性.
- 伊萨夫可纳是一种有价值的抗真菌疗法,用于高风险患者.
- 这些发现对患有复杂潜在疾病的患者尤为重要.
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