评估简化语言对面临患者的药物遗传学报告的影响:一个用户理解研究
Russell Amato1, Nicole M Del Toro-Pagan1, Harris Nguyen1
1Clinical Research & Development and Medical Affairs, Genomind, Inc., King of Prussia, PA 19406, USA.
Journal of personalized medicine
|June 25, 2025
概括
当测试结果被翻译成简单的语言时,患者对药物遗传学 (PGx) 的理解显著改善. 这增强了对遗传变异如何影响药物反应的理解.
科学领域:
- 药物遗传学 药物遗传学
- 遗传学 是一个遗传学.
- 个性化医疗是个性化的医疗.
背景情况:
- 药物遗传学 (PGx) 研究遗传变异如何影响药物反应.
- 提供者和患者对PGx实用性的理解仍然是一个挑战.
- 患者对单一"正确"药物的看法可能会被误导.
研究的目的:
- 评估患者对新开发的,消费者友好的PGx报告的理解程度.
- 评估将复杂的PGx临床术语翻译成普通语言的有效性.
- 测量消费者中药物遗传素养的改善情况.
主要方法:
- 根据消费者理解的商业PGx测试报告进行了调整,确保可读性 ≤8年级.
- 使用Genomind消费者理解调查参与了107名参与者进行分析.
- 使用了经过修改的明尼苏达州药基因素素识别评估 (MAPLTM) 调查前后.
主要成果:
- 在Genomind消费者理解调查 (98/107名参与者) 中实现了>90%的理解率.
- 在调查后,总体PGx识字率在统计学上显著增加.
- 验证了普通语言翻译对PGx信息的有效性.
结论:
- 将PGx测试结果翻译成可访问的语言可以提高患者的理解.
- 简化的PGx报告可以使个人能够理解他们的DNA与药物之间的联系.
- 在PGx中提高患者的识字能力支持了明智的医疗保健决策.
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