人口和临床特征,风险因素和预后在土耳其的带疹成年患者:回顾性多中心研究 (VARICOMP-成年人研究)
Esin Senol1, Alpay Azap2, Selda Sayin Kutlu3
1Department of Infectious Diseases, Faculty of Medicine, Gazi University, Ankara 06500, Türkiye.
Infectious disease reports
|June 25, 2025
概括
这项针对土耳其成人疹子 (HZ) 的大型研究发现,年龄较大,潜在疾病和免疫抑制增加了住院的风险. 建议在高风险群体进行早期抗病毒治疗和接种疫苗,以预防HZ并发症,如后神经疼痛 (PHN).
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,疹 (HZ) 发病率正在上升.
- 在土耳其,关于HZ负担,风险因素和临床特征的综合数据有限.
- VARICOMP-成年人研究解决了这一知识差距.
研究的目的:
- 在土耳其评估HZ的成年患者的临床和人口统计发现.
- 确定与HZ住院和后神经疼痛 (PHN) 相关的风险因素.
主要方法:
- 从1955名成年HZ患者的医疗记录 (2009-2014) 的回顾性分析.
- 纳入标准:年龄在18-97岁之间的患者.
- 后勤回归用于确定住院和PHN的风险因素.
主要成果:
- 35.5%的患者有潜在的疾病;17.6%的患者有免疫抑制.
- 住院率为18.0%;在老年,免疫抑制患者和并发病患者中更高.
- 住院的危险因素包括年龄,免疫抑制,高血压,血液学疾病,移植,COPD,HZ眼科医生和传播疾病. 年龄和缺乏先前的抗病毒使用是PHN (9.9%的发病率) 的风险因素.
结论:
- 这是土耳其对成年HZ进行的最大的全国性研究.
- 抗病毒疗法和免疫等有效干预措施至关重要,特别是在老年人和高风险人群中.
- 有针对性的医疗保健策略可以帮助对抗HZ及其并发症.
相关概念视频
Prevalence and Incidence
838
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
838
Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
71
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
71
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
42
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
42
Hypertension III: Clinical Manifestations and Diagnostic Studies
59
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
59
Pericarditis II: Clinical Features and Diagnostic Tests
33
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
33


