疲劳及其与多发性硬化症患者上肢功能的关联
Erica Grange1,2, Davide Marengo3, Rachele Di Giovanni2
1Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), 16126 Genova, Italy.
Neurology international
|June 25, 2025
概括
多发性硬化症 (PwMS) 患者的疲劳显著影响上肢 (UL) 功能,影响主观能力和力量和灵敏度的客观测量. 解决疲劳对于改善UL功能和指导PwMS中康复策略至关重要.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 临床心理学 临床心理学
背景情况:
- 疲劳是多发性硬化症 (MS) 的普遍和衰弱症状之一.
- 在MS (PwMS) 患者中,疲劳和上肢 (UL) 功能之间的关系需要进一步研究.
- 了解这种关联对于有效的患者管理和康复至关重要.
研究的目的:
- 调查PwMS中疲劳严重程度和UL功能之间的关联.
- 探索疲劳 (身体,认知) 和UL损伤的不同方面之间的关系.
- 为了确定疲劳对主观和客观的手和手臂功能的影响.
主要方法:
- 横截面研究涉及来自意大利五个多发性硬化中心的261名成年PwMS患者.
- 使用修改疲劳影响量表 (MFIS) 评估疲劳.
- 通过盒子和块测试 (BBT),九孔测试 (9HPT) 和手握强度 (HGS) 评估UL功能.
主要成果:
- 在疲劳严重程度,UL功能和患者报告的手动能力之间发现了显著的相关性.
- 身体和认知疲劳的组成部分独立地与功能障碍有关.
- 临床相关疲劳的PwMS表现出较低的主观UL功能,BBT和HGS表现较差,HGS不对称性增加.
结论:
- 在PwMS中,疲劳明显与UL功能的主观和客观测量有关.
- 手的力量和灵敏度都是对感知疲劳的重要因素.
- 整合力量和灵敏度的评估与疲劳评估一起,可以提高临床理解,并为PwMS提供有针对性的康复策略.
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