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Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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皮拉津胺与异亚胺对它们对小鼠肝脏血红蛋白生物合成途径的影响的比较

Fu-Ying Qin1, Ruizhi Gu1, Jiaojiao Zhang1

  • 1Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 335 Sutherland Drive, Pittsburgh, PA 15261, USA.

Metabolites
|June 25, 2025
PubMed
概括

异化 (INH) 通过改变血红素合成酶来加剧病,导致有毒中间体的积累. 皮拉津胺 (PZA) 没有表现出这种影响,这表明其在病患者的禁用可能是不合理的.

关键词:
氨基levulinic 酸合成酶的使用.铁甲酸盐酸酶 (Ferrochelatase) 是一种铁甲酸盐.异化是一种异化.波尔菲里亚症 波尔菲里亚症皮拉津胺的使用方法

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Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
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Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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