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桥梁民族植物学知识和多奥米克的方法植物衍生的天然产品发现的发现

Kekeletso H Chele¹, Lizelle A Piater¹, Justin J J van der Hooft^1,2

¹Department of Biochemistry, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa.

|June 25, 2025

概括

通过将传统的民族植物学知识与现代的多种植物学策略相结合,发现用于医学的植物性天然产品 (NP) 得到了增强. 这种整合加速了从药用植物中识别和开发新疗法.

科学领域:

自然产品的发现自然产品的发现
民族植物学民族植物学
生物信息学是一种生物信息学.
多个omics的多个omics.

背景情况:

植物衍生天然产品 (NP) 历来提供了关键的药品,以传统的民族植物学知识为指导.
传统的NP隔离方法是低效的,并且有可能失去生物活性化合物的特性.
奥米克科学和计算工具的进步为NP研究提供了新的途径.

研究的目的:

探索传统医疗知识与多奥米克战略的整合,以加强NP发现.
在NP研究中强调现代生物信息学工具,质谱和代谢基因组学.
讨论挑战,并提出在药物开发中整合omics数据的策略.

主要方法:

对文献的审查,将人种植物学与多omics方法相结合.
突出生物信息学工具用于代谢物识别和注释.
讨论质谱学和代谢基因组学技术.

主要成果:

人类植物学和多学科的整合显著提高了NP发现效率.
新兴的生物信息学和分析技术加速了代谢物表征.
数据整合策略可以克服当前的研究挑战.

结论:

将传统智慧与现代奥米克科学相结合,彻底改变了NP发现.
这种综合方法促进了有针对性的NP发现和可持续的药物开发.
新疗法和有效利用药用植物是关键成果.

关键词:

计算工具是计算工具.民族植物学民族植物学代谢产物的注释.代谢物识别代谢物识别代谢学代谢学代谢生物组的代谢生物组自然产品是自然产品的产品.配对的奥米克斯传统医学的传统医学.

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