血TMAO度和肠道微生物群组成在有或没有代谢综合征的受试者:试点研究的结果
Mohammed E Hefni1,2, Cornelia M Witthöft1, Patrik Hellström3
1Department of Chemistry and Biomedical Sciences, Linnaeus University, 392 31 Kalmar, Sweden.
Metabolites
|June 25, 2025
概括
代谢综合征 (MetS) 与促进炎症的肠道细菌有关,而不是三甲基胺N氧化物 (TMAO) 生产. 肠道微生物群的转变,而不是TMAO,似乎是通过炎症途径驱动早期的MetS.
科学领域:
- 微生物组研究的研究.
- 代谢综合征是代谢综合征.
- 肠道微生物群和炎症的发生
背景情况:
- 三甲基胺N氧化物 (TMAO) 是一种与非传染性疾病相关的肠道微生物依赖代谢物.
- 代谢综合征 (MetS) 是一组疾病,增加患心脏病,中风和糖尿病的风险.
研究的目的:
- 为了研究有或没有MetS.的个体之间的肠道微生物群组成的差异.
- 为了比较含有和没有MetS.的受试者的TMAO和相关代谢物的血度.
- 探索肠道微生物群概况与MetS特征之间的关联.
主要方法:
- 通过16S rRNA测序分析便样本,以进行肠道微生物群的分析.
- 血样本分析了TMAO,甲基胺,葡萄糖,脂质和HbA1c.
- 临床测量包括血压,体重指数和腰围.
主要成果:
- 患有MetS的受试者表现出微生物多样性减少,Blautia glucerasea较低,Ruminococcus扭矩较高,表明与炎症相关的肠道微生物群.
- 两组之间没有发现血TMAO或相关甲基胺的显著差异;L-卡尼丁在MetS受试者中升高.
- 在TMAO和三甲基胺 (TMA) 之间观察到正相关性,以及与肉素相关的倾向.
结论:
- MetS与肠道微生物群有关,有利于炎症而不是TMAO生产.
- 在没有心血管疾病或2型糖尿病等并发症的情况下,TMAO可能不是MetS的重要因素.
- 肠道微生物群在早期MetS中的作用很可能是由特定细菌转移的炎症机制调解的.
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