相关实验视频

Updated: Sep 18, 2025

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

对Mycobacterium avium复杂肺部分离物的静脉和吸入性阿米卡辛断裂点报告的影响

Christian M Gill^1,2,3,4, Robin Chamberland^5,6, Getahun Abate³

¹Department of Pharmacy, SSM Health Saint Louis University Hospital, Saint Louis, MO 63104, USA.

Pathogens (Basel, Switzerland)

|June 25, 2025

概括

吸入的阿米卡辛与静脉注射的阿米卡辛相比,对Mycobacterium avium复合体 (MAC) 肺部疾病的易感率更高. 这一发现对于优化MAC治疗策略至关重要.

科学领域:

肺部医学肺部医学
传染性疾病传染性疾病
临床微生物学临床微生物学

背景情况:

治疗Mycobacterium avium复合体 (MAC) 肺部疾病是具有挑战性的,因为多种药物治疗方案和潜在的毒性.
临床和实验室标准研究所 (CLSI) 提供了MAC治疗药物的断点,包括静脉注射 (IV) 和吸入阿米卡辛的不同标准.

研究的目的:

用IV和吸入治疗的断点来评估MAC肺部隔离物中的阿米卡辛敏感性.
为了确定非易受阿米卡辛的分离物 (通过IV断点) 的比例,这些分离物仍然对吸入的阿米卡辛敏感.

主要方法:

对MAC肺部隔离物的回顾性队列研究.
根据CLSI指导方针对阿米卡辛 (IV和吸入),克拉里思罗米辛,莫西弗洛克萨辛和线索利德进行敏感性测试.
分析了每名患者每年的一种隔离物.

主要成果:

99.5%的分离物对吸入的阿米卡辛敏感,而对IV阿米卡辛敏感度为94%.
93%的对IV阿米卡辛不敏感的分离物仍然对吸入的阿米卡辛敏感.
对其他药物的敏感率:克拉里思罗米辛 (97%),莫西素 (82%) 和线索利德 (66%).

结论:

吸入的阿米卡辛在MAC肺部隔离物中表现出比IV阿米卡辛更高的敏感率.
实验室应报告IV和吸入阿米卡辛敏感性标准,以指导治疗决策.
这种区分至关重要,以防止忽视MAC肺部疾病的潜在治疗阿米卡辛选择.

关键词:

这种复杂的菌株是Mycobacterium avium.阿米卡辛脂质体吸入悬浮剂吸入悬浮剂敏感性测试解释标准的解释标准

更多相关视频

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Antibiotic Efficacy Testing in an Ex vivo Model of Pseudomonas aeruginosa and Staphylococcus aureus Biofilms in the Cystic Fibrosis Lung

Published on: January 22, 2021

Antimicrobial Susceptibility Testing of Mycobacterium Tuberculosis Complex for First and Second Line Drugs by Broth Dilution in a Microtiter Plate Format

Antimicrobial Susceptibility Testing of Mycobacterium Tuberculosis Complex for First and Second Line Drugs by Broth Dilution in a Microtiter Plate Format

Published on: June 24, 2011

相关概念视频

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...