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来自红树林衍生的真菌Daldinia eschscholzii HJX1P2 的新生物活性多基化物

Miao Yu^1,2, Yikang Qiu^1,2, Shiji Chen^1,2

¹Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.

|June 25, 2025

概括

这项研究从红树林真菌中分离出新型化合物,揭示了潜在的抗炎和抗氧化特性. 化合物1抑制了氧化的产生和素-6的表达,而其他化合物则表现出激素清除和抗菌活性.

科学领域:

自然产品化学自然产品化学
药用化学医学化学
菌类学菌类学是指菌类学.

背景情况:

红树林生态系统拥有多样化的微生物,有可能发现新的生物活性化合物.
菌的二次代谢产物是药理学相关分子的丰富来源.

研究的目的:

从红树林衍生的真菌Daldinia eschscholzii*中分离和描述新的化学实体.
评估分离的化合物的抗炎,抗氧化和抗菌潜力.

主要方法:

使用色谱技术分离和净化真菌代谢物.
通过核磁共振 (NMR) 和质谱法 (MS) 阐明结构.
生物活性测定包括氧化抑制,激素清除 (DPPH,ABTS+) 和抗菌测试对*黄金葡萄球菌*.

主要成果:

确定了三种新的纳烯-二元 (达尔迪纳A-C) 和两种新的衍生物 (达尔迪A-B),以及五种已知的化合物.
化合物1显著抑制了氧化 (NO) 生产,并抑制了 lipopolysaccharide (LPS) 诱导的 RAW 264.7 细胞中的介质素-6 (IL-6) 表达.
化合物7和8表现出强大的2,2-二-1-皮克里水 (DPPH) 基清除活性,而化合物4和10显示出显著的ABTS+基清除活性.
化合物1-3,7和9表现出抗菌活性对*黄金葡萄球菌*菌株.

结论:

这项研究成功地隔离和表征了来自Daldinia eschscholzii的新型和已知的化合物.
化合物1通过抑制NO和IL-6的产生,显示出作为一种抗炎剂的前景.
几种分离的化合物具有抗氧化和抗菌特性,需要进一步研究治疗应用.

关键词:

达尔迪尼亚·埃什斯科尔齐亚 (Daldinia eschscholzii) 是一个古老的植物.它具有抗菌活性,具有抗菌活性.它具有抗炎活性,具有抗炎活性.抗氧化剂活性抗氧化剂活性纳夫他烯克罗曼二次体

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