在不同年龄的健康循环马中,外周血清激素在血液细胞中的参与
Katiuska Satué1, Deborah La Fauci2, Pietro Medica2
1Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, CEU-Cardenal Herrera University, Tirant lo Blanc, 7, Alfara del Patriarca, 46115 Valencia, Spain.
Veterinary sciences
|June 25, 2025
概括
老龄化的母马显示血清素 (5-HT) 和白细胞 (WBC) 数量下降,影响免疫功能. 这些与年龄相关的变化揭示了循环马中5-HT和血液细胞之间的显著相关性.
科学领域:
- 生殖内分泌学和免疫学 生殖内分泌学和免疫学
- 马的生理学和老龄化
背景情况:
- 雌性循环涉及激素变化,影响血清素 (5-HT) 和免疫细胞活性.
- 在整个周期中,雌激素和孕会以不同的方式调节5-HT合成和免疫功能.
- 衰老会改变荷尔蒙特征,可能会影响马的5-HT动态和细胞反应.
研究的目的:
- 为了研究血清素 (5-HT) 和循环马匹的血细胞之间的关系.
- 评估衰老对这些相互作用的影响.
- 了解对马的生殖健康和免疫调节的影响.
主要方法:
- 25只健康,循环的西班牙纯种马匹被分为年轻 (4-9岁) 和老年 (10-15岁) 组.
- 在整个雌激素周期中测量了血清素 (5-HT) 度和白细胞 (包括中性粒细胞,淋巴细胞,单细胞) 计数.
- 还分析了血小板 (PLT) 计数和中性粒细胞与淋巴细胞 (N/L) 的比率.
主要成果:
- 较年长的母马在特定的周期阶段表现出较低的5-HT度,相比较年轻的母马.
- 老化的母马显示白血球,中性粒细胞和淋巴细胞数量减少,特别是在周期后期.
- 与年轻的母马相比,年长的母马的血小板数量较高,单细胞数量有所改变.
结论:
- 衰老显著影响循环马的5-HT度和血细胞概况.
- 老马的5-HT减少和免疫细胞数量改变表明与年龄相关的免疫调节.
- 这些发现突出了5-HT和血液细胞之间的年龄相关关系,影响了马的健康.
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