微塑料作为新兴污染物和人类健康:探索胃结肠大脑轴癌症中的功能营养
Maria Scuto1, Cinzia Maria Grazia Lombardo2, Bruna Lo Sasso1
1Department of Medicine and Surgery, "Kore" University of Enna (UKE), 94100 Enna, Italy.
Toxics
|June 25, 2025
概括
微塑料 (MP) 构成健康风险,导致炎症和细胞损伤. 功能性营养,富含黄素,可以减轻MP毒性,并降低胃-结肠-大脑轴沿癌症的风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 营养科学 营养科学
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,其生物持久性和积累性越来越大.
- 暴露于MP与氧化应激,炎症和胃,结肠和大脑等重要器官的细胞功能障碍有关.
- 这引发了人们对它们在胃-结肠-大脑轴沿癌症发生中的潜在作用的担忧.
研究的目的:
- 审查微塑料暴露与癌症风险之间的相关性.
- 为了确定受MPs影响的信号通路.
- 探索功能营养和生物活性化合物的潜力,以减轻MP诱导的毒性.
主要方法:
- 文献综述,重点关注微塑料毒性和癌症风险.
- 对MP暴露中涉及的信号通路的分析.
- 功能营养素,黄素和多纳米颗粒作为保护剂的评估.
主要成果:
- 暴露于MP可以诱导氧化应激,炎症和细胞功能障碍,可能增加癌症风险.
- 生物活性化合物如黄和多纳米颗粒在增强细胞弹性和排毒方面表现有前途.
- 功能营养素激活Nrf2通路是缓解MP损伤的关键机制.
结论:
- 功能营养,特别是生物活性黄类,为抵消微塑料诱导的毒性提供了一个有希望的策略.
- 这些营养方法可以加强关键障碍 (胃,肠道,大脑) 的细胞防御.
- 整合先进技术和识别分子标可以为针对环境诱导癌症的个性化医学策略铺平道路.
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