制药污染物发生情况和生态风险评估 沿罗马尼亚黑海沿岸
Vasile-Ion Iancu1, Laura-Florentina Chiriac1, Iuliana Paun1
1National Research and Development Institute for Industrial Ecology-ECOIND, Drumul Podu Dambovitei Street, 57-73, Sector 6, 060652 Bucharest, Romania.
Toxics
|June 25, 2025
概括
布洛芬和咖啡因等药品污染了罗马尼亚的黑海水域,对海洋生物构成生态风险. 这项研究强调,迫切需要监测和管理这些抗炎药物残留物.
科学领域:
- 环境化学环境化学
- 海洋生物学 海洋生物学
- 生态毒理学 生态毒理学
背景情况:
- 药物化合物,特别是抗炎药物,在全球海洋环境中越来越多地被检测到.
- 黑海生态系统容易受到人为污染的影响,包括新出现的污染物.
- 评估药品的生态风险对于海洋生态系统健康至关重要.
研究的目的:
- 调查罗马尼亚黑海沿岸海水中的抗炎药物化合物的存在和度.
- 评估这些检测到的药品对敏感的海洋生物构成的生态风险.
- 确定研究区域中药物污染的潜在来源.
主要方法:
- 固体相提取 (SPE) 用于样品制备.
- 液体染色学分离与双重质谱检测 (LC-MS/MS) 结合,用于化合物识别和量化.
- 基于确定的度和毒性数据的生态风险评估 (ERA).
主要成果:
- 在海水样本中检测到ibuprofen,ketoprofen,diclofenac和naproxen. 在海水样本中检测到ibuprofen,ketoprofen,diclofenac和naproxen. 在海水样本中检测到ibuprofen,ketoprofen,diclofenac和naproxen.
- 咖啡因是检测到的最丰富的药物化合物,其最大度达到13,575 ng/L.
- 检测到的药物的最大度按照以下顺序进行:咖啡因 > 伊布洛芬 > 纳普罗 > 迪克洛芬纳克 > 托芬.
- 纳普罗-迪克洛芬和迪克洛芬-基托之间的强烈相关性表明了常见的污染源.
- 生态风险评估表明,咖啡因和布洛芬对皮动物,甲类动物和鱼类构成高风险.
结论:
- 罗马尼亚黑海沿岸被抗炎药物化合物污染.
- 咖啡因和布洛芬对主要海洋物种构成重大生态风险.
- 需要进一步的研究和监测,以减轻黑海的制药污染.
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