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腰椎间盘的建模:ex-vivo机械模型的审查和与临床数据的比较
Thomas David Slater1, Hans-Joachim Wilke2, Gnanaprakash Gurusamy3
1Department of Bioengineering, Imperial College London, London, United Kingdom.
概括
本综述将ex-vivo腰椎间盘的模型与临床数据进行比较. 虽然模型提供了洞察力,但它们的生理相关性各不相同,需要仔细选择,以准确研究椎间盘裂机制.
科学领域:
- 生物机械工程 生物机械工程
- 整形外科的研究研究.
- 脊柱力学 脊柱力学
背景情况:
- 活体模型对于研究腰椎间盘的研究至关重要.
- 目前的模型缺乏对临床数据的验证,质疑它们的形态准确性.
- 本综述旨在通过将现有模型与现实世界病理学的比较来弥合这一差距.
研究的目的:
- 为了对比临床的腰椎间盘的特征.
- 评估现有的ex-vivo模型的形态准确性.
- 确定最相关的模型,以改善未来的研究.
主要方法:
- 按照PRISMA指南进行系统审查.
- 确定了临床研究和ex-vivo腰椎间盘缺陷模型.
- 按负载条件 (复杂的终极压缩,周期性,内部压缩) 分类模型,并与临床数据进行比较.
主要成果:
- 最常见的:挤出 (50%) 和突出 (34%),主要是在L4-L5/L5-S1.1的半中心.
- 状纤维缺陷 (35-81%) 和末端板结合缺陷 (19-68%) 是常见的.
- 所有测试的负载类型都诱导了,但损伤模式不同 (例如,复杂的压缩导致骨折,循环导致环状损伤).
结论:
- 临床纹模式是可变的;ex-vivo模型显示可重复的结果.
- 循环,复杂的终极压缩和内部压缩模型提供了洞察力,但在生理相关性方面有所不同.
- 选择模型需要考虑负载相关性和物种差异;未来的研究应该集中在的进展和预防上.
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