来自神经内分泌新生体的腹膜转移的管理共识指南
David G Su1, Leanne M Brown1, Varun V Bansal1
1Yale School of Medicine, New Haven, CT, USA.
Annals of surgical oncology
|June 25, 2025
概括
这一共识为带有腹膜转移 (NEN-PM) 的神经内分泌瘤提供了临床指导. 管理策略因NEN级别而异,强调低级别的手术和高级别NEN-PM的全身治疗.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 带有腹膜转移的神经内分泌瘤 (NEN-PM) 存在复杂的管理挑战,因为它们的罕见性和特征多样化.
- 现有的临床指南需要更新,以反映NEN-PM的当前理解和治疗方法.
研究的目的:
- 建立关于诊断为NEN-PM.患者的临床管理的国家共识.
- 根据专家的共识和现有证据,更新和完善NEN-PM的现有指南.
主要方法:
- 采用了经过修改的Delphi技术,涉及两轮专家投票以达成共识.
- 内容专家总结了主要的全身疗法概念,并通过快速的文献审查进行了支持.
- 在各种临床途径组件中评估了参与者同意水平.
主要成果:
- 在大多数路径块上达成了高度共识 (>90%),这表明专家之间存在强烈的共识.
- 强烈建议对NEN-PM患者采取多学科的方法,包括心理社会支持.
- 管理建议按NEN级分层分类:对1~2级NEN-PM有很好的区别的细胞削减手术,对3级NEN-PM有系统治疗.
结论:
- 基于共识的临床途径为管理NEN-PM提供了必要的指导,特别是考虑到有限的高质量证据.
- 需要进行进一步的研究,以产生可靠的证据来优化NEN-PM治疗策略.
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