关于围性间皮瘤管理的共识指南
Leanne M Brown1, Sarah G Wilkins1, Varun V Bansal1
1Yale School of Medicine, New Haven, CT, USA.
Annals of surgical oncology
|June 25, 2025
概括
腹膜间皮瘤 (PeM) 的治疗指南是根据国家共识更新的. 该共识为管理PeM提供了一条途径,强调多学科护理和临床试验,因为证据有限.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 临床共识 临床共识
背景情况:
- 腹膜间皮瘤 (PeM) 由于罕见性,异质性和证据有限而存在治疗挑战.
- 为了解决PM的管理问题,召开了全国共识.
- 对于PeM治疗的现有临床证据很少.
研究的目的:
- 更新2018年芝加哥共识指南,用于腹膜间皮瘤的管理.
- 建立一个共识驱动的PM临床途径.
- 为PM的多学科评估和治疗提供指导.
主要方法:
- 采用了修改后的Delphi技术,涉及两轮投票.
- 邀请了101名参与者,其中95人 (94%) 在第二轮中回应了邀请.
- 在定义的路径块中评估了共识水平.
主要成果:
- 在5/6 (第一轮) 和6/6 (第二轮) 路径块中达成90%以上的共识.
- 建议对良性瘤进行观察;根据症状/特征指导干预.
- 恶性病理管理依赖于多学科评估,强调中等/高风险患者的多式疗法.
- 有限的数据存在于最佳的全身治疗时间;支持临床试验招生.
结论:
- 在有限的证据中,共识驱动的途径为PeM管理提供了必要的指导.
- 需要进一步的专门研究来产生更高质量的PeM证据.
- 多学科方法和临床试验参与对于推进PeM护理至关重要.
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