血清激素神经元对于抑制性摄入是必要的
Silvia Gasparini1, Gordon F Buchanan1,2, Joel C Geerling1,2
1Department of Neurology, University of Iowa, Iowa City, Iowa, United States.
概括
血清能神经元作为一种制动盐的消耗. 缺乏这些神经元的小鼠增加了盐的摄入量,这表明它们在调节食欲和防止过多的消耗方面发挥了关键作用.
科学领域:
- 神经科学是一个神经科学.
- 生理学 生理学 生理学
- 行为科学 行为科学
背景情况:
- 食欲是一个关键的动机行为,特别是在缺乏的情况下.
- 血清素是一种神经递质,参与调节各种动机行为,包括摄入.
- 在控制食欲方面,能神经元的确切作用尚未完全阐明.
研究的目的:
- 通过基因删除来研究血清能神经元对于调节食欲的必要性.
- 为了确定 serotonergic 神经元是否作为车或驱动器的摄入量.
- 评估血清能神经元删除对口渴和食欲抑制的影响.
主要方法:
- 利用一种遗传模型 (Pet1-Cre;Lmx1bflox/flox小鼠) 几乎完全删除了神经元.
- 在突变和对照小鼠中测量了基线水和3%的NaCl摄入量.
- 评估了缺水后的口渴反应和胺诱导的尿路和缺后的食反应.
主要成果:
- 与对照组 (Lmx1b(f/f/f)) 相比,缺乏神经元的神经元 (Lmx1b(f/f/p)) 的小鼠的盐摄入量显著增加.
- 对缺水的口渴反应在缺乏血清能神经元的小鼠中是完整的.
- 对缺乏的食反应也完好无损,观察到盐和水摄入量增加.
- 在突变小鼠中,基线每日盐摄入量在研究期间逐渐增加.
结论:
- 血清能神经元对于启动食或口渴并非必不可少,而是作为消耗的增强抑制车.
- 这种抑制作用表明,对过多的摄入有保护机制.
- 研究结果表明,血清能系统的调节可能会影响饮食中的消费模式.
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