晚期发作的胎儿生长限制婴儿的神经发育
Liqun Sun1,2,3, Fu-Tsuen Lee3,4,5, Natasha Milligan3,4
1Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education) and Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
JAMA network open
|June 25, 2025
概括
晚期发病的胎儿生长限制 (FGR) 的满期婴儿在18个月时表现出正常的神经发育. 更长的孕期与更好的结果相关,这表明早期分娩可能不会对神经发育有好处.
科学领域:
- 围产儿医学 围产儿医学
- 神经发育儿科 神经发育儿科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 胎儿生长限制 (FGR) 与不良的神经发育结果有关.
- 诊断晚发性FGR和解释早产使理解其特定的神经发育后续变得复杂.
研究的目的:
- 评估暴露于晚期发作的FGR.GR的满期婴儿的神经发育结果.
- 调查FGR,胎儿血动力学,大脑发育和生长之间的关联.
主要方法:
- 一个单一中心的队列研究招募了怀孕个体,他们的胎儿对于妊娠年龄来说很小.
- 用阿尔伯塔婴儿运动尺度和贝利尺度评估神经发育,直到36个月.
- 使用MRI评估胎儿血液动力学和大脑发育.
主要成果:
- 暴露于晚期发作的FGR的满期婴儿在12个月时显示出运动发育延迟,但在其他时间点具有类似的神经发育.
- 出生时的妊娠年龄,而不是FGR诊断,与18个月的认知结果有关.
- 患有FGR的早产婴儿已经改变了胎儿的血液动力学;然而,在36个月的FGR暴露的婴儿中,头周长较小.
结论:
- 被暴露于晚期发作的FGR的满期婴儿在18-36个月时表现出正常的神经发育.
- 更长的孕期与改善的结果有关,这表明早产可能不有益.
- 晚期发病的FGR对满期婴儿的神经发育的不良影响似乎很小.
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