相关实验视频

Updated: Sep 8, 2025

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

在嗅觉神经母细胞瘤组织中癌症干细胞的表征

Shivani Ramolia^1,2, Riley Larkin^1,3, Yvette Robbins⁴

¹Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

International forum of allergy & rhinology

|June 25, 2025

概括

癌症干细胞在嗅觉神经母细胞瘤中很罕见. 如果发现,这些癌症干细胞经常表达PD-L1,这是潜在的治疗点.

科学领域:

在瘤学瘤学.
病理学病理学病理学

背景情况:

嗅觉神经母细胞瘤 (ONB) 是一种罕见的恶性瘤.
癌症干细胞 (CSCs) 参与瘤的开始和进展.
在ONB中CSCs和PD-L1表达的作用尚不清楚.

研究的目的:

研究嗅觉神经母细胞瘤中癌症干细胞的存在和特征.
确定癌症干细胞与ONB中的PD-L1表达之间的关联.

主要方法:

免疫组织化学被用来检测癌症干细胞标记物.
用免疫组织化学染色来评估PD-L1表达.
在CSC和PD-L1阳性之间进行了相关性分析.

主要成果:

在分析的嗅觉神经母细胞样本中,癌症干细胞很少被发现.
鉴定到的癌症干细胞中有很大一部分呈现出积极的PD-L1表达.
虽然CSC的存在并不常见,但与PD-L1阳性有关.

结论:

癌症干细胞在嗅觉神经母细胞瘤中不常见.
当存在时,嗅觉神经母细胞瘤中的癌症干细胞更有可能是PD-L1阳性.
在CSC上的PD-L1表达可能代表嗅觉神经母细胞瘤的潜在治疗脆弱性.

关键词:

癌症干细胞是一种癌症干细胞.这是一个神经母细胞瘤.免疫疗法免疫疗法嗅觉神经母细胞瘤

更多相关视频

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

相关概念视频

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...