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Updated: Sep 18, 2025

Technique for Intranasal Administration of α-Synuclein Aggregates
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Published on: November 8, 2024

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诱导α-Synuclein液态相分离的

Tatsuya Ikenoue1,2, Masatomo So3, Naohiro Terasaka1

  • 1Department of Chemistry, The University of Tokyo, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|June 25, 2025
PubMed
概括

研究人员设计了新型来控制蛋白质液相分离 (LLPS),这是帕金森病的一个过程. 这些诱导和调节α-synuclein的LLPS,为神经退行性疾病提供潜在的治疗策略.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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