运动后,与葡萄糖同时服用单,可刺激小鼠肌肉中的糖原补充
Yumiko Takahashi1, Tatsuya Matsumoto1, Wenxin Wang1
1Department of Sports Sciences, The University of Tokyo, Tokyo, Japan.
American journal of physiology. Cell physiology
|June 25, 2025
概括
运动后摄入的单增强了肌肉糖原的补充,特别是在缓慢缩的纤维中. 这项研究发现,在补充剂后,缓慢抽的肌肉中改善了糖原储存,但对快速抽的纤维没有影响.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 骨肌肉的新陈代谢
背景情况:
- 关于体补充对运动后肌肉糖原补充的影响,体内存在相互矛盾的结果.
- 以前的研究表明,β-基酸盐刺激了孤立的骨肌肉中的糖原补充.
- 在体内,单对不同类型肌肉纤维的影响尚不清楚.
研究的目的:
- 为了研究口服单质摄入量对小鼠运动后肌肉糖原补充的作用.
- 为了比较对缓慢抽的纤维占主导地位的足部肌肉和快速抽的纤维占主导地位的植物肌肉的影响.
- 检查血糖,血胰岛素和AMPK酸化的相关变化.
主要方法:
- 鼠标接受了跑步机运动,然后用单 (KE溶液) 或三 (Con溶液) 口服葡萄糖.
- 肌肉糖原度在肌肉和植物肌肉中被测量在服药后60分钟.
- 血糖,血胰岛素和肌底肌肉AMPK酸化被评估在特定的时间点.
主要成果:
- 与对照组相比,KE治疗组表现出较低的血糖和较高的血胰岛素水平.
- 单体肌肉糖原度在KE治疗组与Con组相比,在KE治疗组高出42.1%.
- 在两组之间,植物肌中没有观察到糖原度的显著差异;KE后的单体AMPK酸化减少.
结论:
- 运动后,口服摄入基单增强了缓慢抽的纤维主导的骨肌肉中的糖原补充.
- 单没有显著影响快速缩纤维占主导地位的骨肌肉中的糖原补充.
- 单的摄入影响葡萄糖-胰岛素动态,并减少AMPK激活在缓慢抽肌肉运动后.
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