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Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
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通过经过验证的多尺度建模方法,评估心脏功能从微重力到超重力条件.

Francesco Tripoli1, Luca Ridolfi2,3, Stefania Scarsoglio1,3

  • 1Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

The Journal of physiology
|June 25, 2025
PubMed
概括

计算建模揭示了重力变化如何影响心脏功能,在微重力中显示了心脏效率的提高,在超重力中显示了能量供应的受损,这对太空医学至关重要.

关键词:
心脏血动力学心脏血动力学进行心血管模型设计.超重力是一种超重力.微重力中的微重力.太空医学 太空医学

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科学领域:

  • 心血管生理学心血管生理学
  • 太空医学 太空医学
  • 计算建模计算建模

背景情况:

  • 变化的重力 (微重力和超重力) 会导致显著的心血管变化,包括液体转移和静止性低血压.
  • 由于实验的局限性,在这些极端条件下了解心脏功能具有挑战性.

研究的目的:

  • 开发和验证一个多尺度心血管模型 (0D-1D),用于研究急性心脏对重力变化的反应.
  • 分析心脏血液动力学从0g到3g,专注于左和右心脏功能之间的差异.

主要方法:

  • 开发了0D-1D多尺度心血管模型,整合了动脉,冠状动脉和外周循环.
  • 该模型包含短期监管机制,并考虑重力和姿势变化.
  • 模型验证是使用已公布的数据对心率和平均动脉压等中央血液动力学参数进行的.

主要成果:

  • 该模型准确地预测了重力范围 (0g到3g) 的中央血液动力学参数.
  • 微重力 (0g) 证明了心脏效率和表现的提高.
  • 超重力 (3g) 显示心脏效率降低,心脏和冠状动脉水平的能量供需平衡受损.

结论:

  • 经过验证的计算模型为改变重力的心脏功能提供了洞察力,补充实验数据.
  • 这种方法对于了解太空医学挑战和极端环境的生理影响是有价值的.
  • 这项研究突出了心脏左侧和右侧不同的反应,并确定了超重力中的关键能量平衡问题.