智能超长时间持续连续触发和巧妙植入的喷嘴系统,用于按需药物输送,用于慢性治疗
Qi Zeng1,2, Yusheng Gong1,2, Wenhao Jiao1,2
1Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Science advances
|June 25, 2025
概括
我们开发了SUSTAIN,这是一种用于慢性疾病的智能植入式药物输送系统. 它提供超长时间的,精确控制的皮下药物释放,改善患者的服药性和治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统的慢性疾病治疗面临着低药效和患者坚持治疗的挑战.
- 现有的先进的药物输送装置往往是重的,需要经常植入,并带来炎症和不精确控制的风险.
研究的目的:
- 开发一个名为SUSTAIN的智能,超长寿命,顺序可触发和可植入的药物输送系统.
- 克服当前治疗慢性疾病的药物输送方法的局限性,提高治疗疗效和患者的便利性.
主要方法:
- 该SUSTAIN系统集成了透压触发模块,用于调节剂量的气流生成T管 (AGT) 和使用剪切稀释水凝的药物输液 (DIP).
- 剂量通过在AGT中变化的NaHCO3 / KH2PO4粉末量来控制.
- 持续的药物输注是通过DIP中的β-cyclodextrin/Pluronic F-127水凝的剪切稀释特性实现的.
主要成果:
- 在体内研究表明,SUSTAIN系统能够在长时间内提供多剂量药物.
- 该系统成功地在10天内输送了四剂勒沃西酸盐和42天内输送了三剂塞马格卢提德.
- 有效的血液药物水平保持在最小的侵入性,表明成功控制的皮下药物释放.
结论:
- 通过改善药物输送,SUSTAIN系统为治疗慢性疾病提供了一种新且有前途的解决方案.
- 这项技术通过提供超长时间,精确控制和最少侵入性的药物管理来提高治疗结果和患者的便利性.
- 在长期疾病管理的植入式药物输送系统中,SUSTAIN代表了显著的进步.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
473
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
473
01:16Drug Delivery: Overview
429
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
429