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Updated: Sep 18, 2025

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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由心肌细胞衍生的YOD1通过使STAT3脱和稳定,促进病态心脏缩

Bozhi Ye1,2,3, Wante Lin1, Yucheng Jiang3

  • 1Department of Cardiology and the Key Laboratory of Cardiovascular Disease of Wenzhou, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Science advances
|June 25, 2025
PubMed
概括

研究人员发现,二氧化酶YOD1稳定了STAT3,减少了病理性心脏缩. 抑制YOD1或STAT3减轻了心脏重塑,为心脏病提供了新的治疗点.

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