阴性秩序是否允许长长的细胞组更好地感知电场?
Kurmanbek Kaiyrbekov1, Brian A Camley1,2
1William H. Miller III Department of Physics & Astronomy, Johns Hopkins University, Baltimore, MD, United States.
PloS one
|June 25, 2025
概括
细胞形状和对齐影响了细胞群集体对电场的反应. 局部细胞对齐可以改善电场传感,细胞粘附在组准确性中起着关键作用.
科学领域:
- 生物物理学的生物物理.
- 细胞生物学 细胞生物学
- 计算生物学 计算生物学
背景情况:
- 集体细胞迁移对于组织发育,再生和伤口愈合至关重要.
- 外部定向线索,如电场,指导集体细胞行为.
- 细胞形状异构和局部对齐对集体电场响应的影响尚未完全理解.
研究的目的:
- 研究细胞形状异构性和局部细胞对齐如何影响细胞对电场的集体反应.
- 为了确定阴性顺序 (细胞长轴的对齐) 是否提高了细胞组中电场传感的准确性.
- 探索细胞-细胞粘附在调节小组感应电场的精度中的作用.
主要方法:
- 简化细胞模型的模拟,包括异型细胞形状.
- 建模电池取决于方向的电场传感精度.
- 在不同程度的局部细胞对齐和细胞-细胞粘附下对集体细胞行为的分析.
主要成果:
- 长长的电池在感知电场时表现出取决于方向的精度,当与电场垂直对齐时,精度更高.
- 细胞长轴与最近邻居的局部对齐可以在某些条件下 (细胞的方向垂直于平均速度) 增强对电场的集体定向反应.
- 发现细胞对细胞的粘附会调节细胞组在感知电场方面的整体准确性.
结论:
- 细胞形状的异型性和局部细胞对齐是集体细胞对电场反应的重要因素.
- 通过局部细胞与细胞的相互作用,内马学秩序可以提高小组感知电场的能力.
- 细胞-细胞粘附是集体细胞在响应外部定向线索时感知精度的关键调节器.
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