最佳采样频率和废水环境监测和传染病原体环境监测地点的选择:信息评估的价值
Isabella Impalli1, Erik Bergland1, Chadi M Saad-Roy2,3
1One Health Trust, Washington, DC, United States of America.
PLoS computational biology
|June 25, 2025
概括
污水和环境监测 (WES) 提供了感染性疾病的早期检测. 优化采样频率和地点选择最大限度地提高了WES的成本效益,特别是在资源有限的地区.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 数学建模的数学建模
背景情况:
- 污水和环境监测 (WES) 是一种用于早期检测人口中传染病的强大工具.
- 传统的监测方法有局限性,使得WES成为快速发现疫情的有希望的替代方案.
- 工业电路的成本效益是一个关键考虑因素,特别是在资源较低的环境中,需要仔细规划.
研究的目的:
- 开发分析模型并进行数值模拟,以确定 WES 在交互群体中的最佳采样频率.
- 评估信息 (VOI) 对WES策略的价值,并了解其与补丁相互作用的关系.
- 为优化WES实施提供指导,以提高成本效益,重点关注选址和采样频率.
主要方法:
- 使用分析模型和数值模拟来模拟疾病动态和WES策略.
- 该模型分析了两个相互作用的补丁,每个都有一个不同的采样地点.
- 信息价值 (VOI) 评估被用来评估监测的有效性.
主要成果:
- 最佳的WES策略可能涉及在一个相互作用的补丁中进行更频繁的测试,而不是在多个补丁中进行更少的测试,考虑到足够的相互作用,测试灵敏度/特异性和大量的设置成本.
- 监测信息的净值在贴片之间的相互作用程度方面是非单调的.
- 补丁之间混合的增加加快了检测速度,但可能会加剧整体感染负担.
结论:
- 优化WES需要协调地选择监控地点和采样频率,以最大限度地提高监控信息的价值.
- 结果可以为 WES 对传染病的成本效益实施提供信息,特别是在资源有限的环境中.
- 该模型提供了一个可适应特定病原体和种群的高级框架.
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