相关实验视频
Updated: Jun 24, 2026

08:41
Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
9.2K
评论文章:肠道微生物组和益生菌干预措施在儿科急性淋巴细胞白血病中的参与
1Western University of Health Sciences COMP.
Critical reviews in oncogenesis
|June 25, 2025
概括
益生菌显示出通过平衡肠道微生物群来改善儿科急性淋巴细胞白血病 (ALL) 的结果的潜力. 然而,需要仔细研究,以确保在接受癌症治疗的免疫功能低下儿童中安全使用.
科学领域:
- 儿科瘤学 儿科瘤学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 急性淋巴细胞白血病 (ALL) 是一种普遍存在的儿童癌症,治愈率高,但治疗毒性和复发的持续挑战.
- 肠道微生物组在免疫功能中起着至关重要的作用,在ALL患者中经常发生变化,通常因化疗和抗生素而恶化.
- 肠道微生物组的变化可能会影响儿科ALL的治疗疗效和患者结果.
研究的目的:
- 探索益生菌在治疗ALL儿童肠道微生物组中的潜在作用.
- 调查益生菌是否可以减轻与治疗相关的副作用,并改善儿科ALL的整体结果.
- 突出了对免疫功能低下的儿科癌症患者标准化益生菌协议的进一步研究的需要.
主要方法:
- 对小儿ALL肠道微生物组现有文献的综述.
- 对调查癌症患者益生菌干预的研究进行分析,重点关注儿科患者.
- 检查益生菌可能影响免疫功能和治疗反应的潜在机制.
主要成果:
- 在患有ALL的儿童中,肠道微生物组受到显著干扰,影响免疫平衡.
- 某些益生菌菌株显示出恢复微生物平衡和减少与ALL治疗相关的胃肠道副作用的潜力.
- 有证据表明,益生菌使用与改善治疗结果之间可能存在联系,尽管数据有限.
结论:
- 益生菌可能通过调节肠道微生物群并可能减少治疗毒性,为儿科ALL患者提供支持策略.
- 在免疫功能低下的ALL患者中使用益生菌需要仔细考虑,因为存在感染风险.
- 进一步严格的临床试验至关重要,以确定益生菌在儿科ALL中使用益生菌的安全性,疗效和最佳方案.
相关概念视频
Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

