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Updated: Sep 18, 2025

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用于结构分析库林1介导基质多基化的乌比基延伸探针的设计和半合成

Chuntong Li1,2,3, Fangyu Zhao1,2, Chong Zuo2,3

  • 1Center for Bioanalytical Chemistry, Hefei National Laboratory of Physical Science at Microscale, University of Science and Technology of China, Hefei 230026, China.

Journal of the American Chemical Society
|June 25, 2025
PubMed
概括

新的化学探测器可以通过E3链酶进行更长的泛素链形成的结构研究. 这些扩展探测器在多化过程中揭示了不同的形状, 进步了我们对这一关键细胞过程的理解.

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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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