[治疗骨关节炎疼痛恶化并非固定组合的组合疗法]
A V Naumov1, A V Unkovskiy1, N O Khovasova1
1Pirogov Russian National Research Medical University (Pirogov University).
Terapevticheskii arkhiv
|June 25, 2025
概括
与无原蛋白选择相比,将原蛋白添加到二甲酸,葡萄糖胺,MSM和氨酸补充剂显著改善了膝关节骨关节炎疼痛和功能. 这种组合疗法为OA恶化提供了更好的缓解.
科学领域:
- 整形外科 整形外科 整形外科
- 类风湿病学 类风湿病学
- 营养保健品 营养保健品
背景情况:
- 膝关节骨关节炎 (OA) 恶化是一个重大的临床挑战.
- 目前的管理通常涉及症状缓解和生活方式修改.
研究的目的:
- 为了比较一种组合治疗的疗效,包括氏丁硫酸盐 (CS),葡萄糖胺 (GL),甲基硫甲基 (MSM) 和氨酸 (HA) 与或没有原蛋白,用于初始治疗膝关节OA恶化.
主要方法:
- 一项前性,比较性IV期研究将60名膝关节OA患者 (Kellgren-Lawrence阶段2-3) 随机分为两组.
- 组A接受了CS/GL/MSM/HA;组B接受了相同的治疗方案加上原蛋白.
- 在8周内评估了疼痛 (VAS,WOMAC),NSAID使用和功能结果.
主要成果:
- 与A组相比,B组 (用原蛋白) 的WOMAC (76%vs. 47%) 和VAS疼痛得分 (74%vs. 56%) 的降低明显更大.
- 在B组,NSAID使用率较低 (第8周为2.6天而不是4.3天).
- 在B组,功能性改善,包括增加步行速度和减少定时起步测试持续时间,更为明显.
结论:
- 结合CS/GL/MSM/HA和原蛋白的联合治疗对于膝关节OA恶化而言优于无原蛋白治疗.
- 这种方案有效地减少疼痛,增强关节功能,减少对症状治疗的需要.
- 这些发现支持将原纳入OA组合疗法.
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