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Updated: Sep 18, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

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发现了针对PcORP1的PH域的新型抑制剂:虚拟查,结构优化,生物评估

Xingxing Lu1, Xiaofei Liu2, Yu Sun3

  • 1State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, College of Plant Protection, Northwest A&F University, 3 Taicheng Road, Yangling, 712100, China; Innovation Center of Pesticide Research Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.

European journal of medicinal chemistry
|June 25, 2025
PubMed
概括

研究人员发现了化合物X4,一种新的PH域抑制剂,用于与氧化结合蛋白 (OSBP) 相关的蛋白1 (ORP1). 这种新的杀菌剂有效地向虫,为作物保护提供了一个有前途的解决方案.

关键词:
基于对接的虚拟选.杀菌机制是一种杀菌机制.ORP1 的 PH 域.植物植物 (Phytophthora capsicici) 是一种植物.

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