在患有帕金森病的患有手术内动障碍的帕利达活动
Philip Pavlovsky1, Anna Gamaleya2, Svetlana Asriyants2
1Laboratory of Human Cell Neurophysiology, N.N. Semenov Federal Research Center for Chemical Physics Russian Academy of Sciences, 119991, Kosygina str.4, Moscow, Russian Federation; M.V. Lomonosov Moscow State University, Faculty of Biology, 119234, 1-12 Leninskie Gory, Moscow, Russian Federation.
概括
在帕金森病 (PD) 中,Levodopa 治疗对内神经元 (GPi) 的影响比外神经元 (GPe) 的影响更为均. 这表明需要重新评估在PD中β振荡的模型.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 细胞生物学 细胞生物学
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,其特点是运动缺陷.
- 列沃多巴是PD的主要治疗方法,但其对基底质回路的影响很复杂.
- 球体,包括外部 (GPe) 和内部 (GPi) 分段,在运动控制中起着至关重要的作用,并与PD病理生理学有关.
研究的目的:
- 与未服用药物状态相比,研究在接受莱沃多巴的帕金森病患者中GPe和GPi神经元的差异活性.
- 探索勒沃多巴对神经元发射速率,模式和GPe和GPi中的振荡的影响.
主要方法:
- 在深度脑刺激手术期间,在帕金森病患者的GPe和GPi中进行了单个单元活动记录.
- 在接受药物治疗的患有勒沃多巴诱导性运动障碍 (LID) 的患者和未接受药物治疗的患者之间进行了活性比较,这些患者的勒沃多巴反应程度相似.
- 分析的重点是放电率,发射模式和振荡特性.
主要成果:
- 莱沃多巴的使用导致大多数GPi神经元的发射频率和规律性下降,在GPe中观察到的变化不那么均.
- 在任何状态下,GPe或GPi都没有检测到低β (12-20 Hz) 振荡.
- 当服用药物时,几个GPi神经元在4-5 Hz和20-30 Hz范围内表现出振荡性放电.
结论:
- 在单细胞水平上,GPi表现出对levodopa的反应比GPe更一致.
- 研究结果表明,可能需要修改目前的贝塔振荡生成模型,这些模型是在PD的亚thalamic核-GPe-GPi网络内进行.
- 这项研究通过在细胞水平上检查勒沃多巴对基底腺核的影响,增强了对PD病理生理学的理解.
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