因果发现分析揭示了对年轻人的精神病倾向,大脑功能和环境因素的洞察力
Tuba Sahin-Ilikoglu1, Sisi Ma2, Erich Kummerfeld2
1Department of Neuroscience, Bilkent University Aysel Sabuncu Brain Research Center, Ankara, Türkiye; National Magnetic Resonance Research Center (UMRAM), Bilkent University, Ankara, Türkiye.
Psychiatry research. Neuroimaging
|June 25, 2025
概括
负面的自我模式和较低的社会凝聚力可能会因果关系地影响年轻人的精神病易感 (PP). 易患精神病也会影响DLPFC中的大脑活动,这表明了预防的目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 轻微的精神病症状,或精神病易感 (PP),在非临床人群中很常见.
- 了解在发育过程中影响PP的因素至关重要,但不清楚.
- PP可能代表精神病风险的连续性.
研究的目的:
- 在年轻人中探索各种因素和精神病易感 (PP) 之间的因果关系.
- 通过因果发现分析 (CDA) 识别PP的神经和环境贡献者.
- 在健康的双胞胎和兄弟姐妹群体中调查这些关系的方向性.
主要方法:
- 使用因果发现分析 (CDA),一种机器学习算法,对194名健康青少年和年轻成人双胞胎/兄弟姐妹 (年龄14-24岁) 的数据集.
- 在fMRI过程中收集了关于社会人口结构,环境风险,智力,自我方案,精神病易感度 (PPS) 和工作记忆 (WM) 的数据.
- 分析了37个变量,以确定影响PPS的因果途径.
主要成果:
- 负的自我方案显示了对精神病易感 (PPS) 的最大潜在因果影响 (影响大小[ES]=0.54).
- 较低的社会凝聚力和信任也显示出对PPS的潜在因果作用 (ES=-0.18).
- 精神病易感度评分 (PPS) 被确定为增加背侧前额皮层 (DLPFC) 激活的直接原因 (ES=0.12).
结论:
- 负面的自我模式和低的社会凝聚力/信任是可能影响普通人口中PP的重要因素.
- 这些因素代表了旨在降低精神病风险的预防性干预措施的潜在目标.
- 由PP影响的DLPFC激活表明它可能是干预的相关神经点.
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